UNDETECTABLE FOR MANY HIV PATIENTS

IMPORTANT SAFETY INFORMATION:

Do not take REYATAZ if you are allergic to REYATAZ or to any of its ingredients.

Do not take REYATAZ^® (atazanavir sulfate) if you are taking the following medicines due to potential for serious, life-threatening side effects or death:
Versed^® (midazolam) when taken by mouth, Halcion^® (triazolam), ergot medicines (dihydroergotamine, ergonovine, ergotamine, and methylergonovine such as Cafergot^®, Migranal^®, D.H.E. 45^®, ergotrate maleate, Methergine^®, and others),
Propulsid^® (cisapride), or Orap^® (pimozide).

Do not take REYATAZ with the following medicines due to potential for serious side effects: Camptosar^® (irinotecan), Crixivan^® (indinavir), Mevacor^®(lovastatin),Zocor^® (simvastatin), Uroxatral^® (alfuzosin), or Revatio^® (sildenafil).

Do not take REYATAZ with the following medicines as they may lower the amount of REYATAZ in your blood, which may lead to increased HIV viral load and resistance to REYATAZ or other anti-HIV medicines: rifampin (also known as Rimactane^®, Rifadin^®, Rifater^®, or Rifamate^®), St. John's wort (Hypericum perforatum)-containing products, or
Viramune^® (nevirapine).

Serevent Diskus^® (salmeterol) and Advair^® (salmeterol with fluticasone) are not recommended with REYATAZ.

Do not take Vfend^® (voriconazole) if you are taking REYATAZ and Norvir^® (ritonavir).

The above lists of medicines are not complete. Taking REYATAZ^® (atazanavir sulfate) with some other medicines may require your therapy to be monitored more closely or may require a change in dose or dose schedule of REYATAZ or the other medicine. Discuss with your healthcare provider all prescription and non-prescription medicines, vitamin and herbal supplements, or other health preparations you are taking or plan to take.

Tell your healthcare provider if you are pregnant or plan to become pregnant. REYATAZ use during pregnancy has not been associated with an increase in birth defects. Pregnant women have experienced serious side effects when taking REYATAZ with other HIV medicines called nucleoside analogues. After your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow. Do not breastfeed if you are HIV-positive.

Also tell your healthcare provider if you have end-stage kidney disease managed with hemodialysis or severe liver dysfunction.
Tell your healthcare provider right away if you have any side effects, symptoms, or conditions, including the following:

• Mild rash (redness and itching) without other symptoms sometimes occurs in patients taking REYATAZ, most often in the first few weeks after the medicine is started, and usually goes away within 2 weeks with no change in treatment.
• Severe rash may develop with other symptoms that could be serious and potentially cause death. If you develop a rash with any of the following symptoms, stop using REYATAZ^® (atazanavir sulfate) and call your healthcare provider right away:
  • – Shortness of breath
  • – General ill-feeling or "flu-like" symptoms
  • – Fever
  • – Muscle or joint aches
  • – Conjunctivitis (red or inflamed eyes, like "pink-eye")
  • – Blisters
  • – Mouth sores
  • – Swelling of your face
• Yellowing of the skin and/or eyes may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
• A change in the way your heart beats may occur. You may feel dizzy or lightheaded. These could be symptoms of a heart problem.
• Diabetes and high blood sugar may occur in patients taking protease inhibitor medicines like REYATAZ. Some patients may need changes in their diabetes medicine.
• If you have liver disease, including hepatitis B or C, it may get worse when you take anti-HIV medicines like REYATAZ^® (atazanavir sulfate).
• Kidney stones have been reported in patients taking REYATAZ. Signs or symptoms of kidney stones include pain in your side, blood in your urine, and pain when you urinate.
• Some patients with hemophilia have increased bleeding problems with protease inhibitor medicines like REYATAZ.
• Changes in body fat have been seen in some patients taking anti-HIV medicines. The cause and long-term effects are not known at this time.
• Immune reconstitution syndrome has been seen in some patients with advanced HIV infection (AIDS) and a history of opportunistic infection. Signs and symptoms of inflammation from previous infections may occur soon after starting anti-HIV treatment, including REYATAZ.
• Gallbladder disorders (including gallstones and gallbladder inflammation) have been reported in patients taking REYATAZ.

Other common side effects of REYATAZ^® (atazanavir sulfate) taken with other anti-HIV medicines include: nausea; headache; stomach pain; vomiting; diarrhea; depression; fever; dizziness; trouble sleeping; numbness, tingling, or burning of hands or feet; and muscle pain.
You should take REYATAZ once daily with food (a meal or snack). Swallow the capsules whole; do not open the capsules. You should take REYATAZ and your other anti-HIV medicines exactly as instructed by your healthcare provider.